How polypharmacologic is each chemogenomics library?

How is the Mother Tongue Acquired

Platelet Refractoriness and how it is formed

Abstract Background and Objectives Transfusion of platelet has become one of the main treatments for thrombocytopenic patients to reduce the severity and frequency of bleeding consequences. Failure to attain the desired level of platelets in a patient following platelet transfusion is defined as platelet refractoriness. The purpose of present paper is to review and study the mechanisms involve...

How Random is a Corpus ? The Library Metaphor

There is a stark contrast between the random sample model underlying the statistical analysis of corpus frequency data and our intuitive knowledge that sentences are more than random bags of words. The ‘library metaphor’ illustrates how randomness results from the selection of a corpus as the basis for a linguistic study. At the same time it reveals two reasons why corpus data do not fully meet...

Computational chemogenomics: Is it more than inductive transfer?

High-throughput assays challenge us to extract knowledge from multi-ligand, multi-target activity data. In QSAR, weights are statically fitted to each ligand descriptor with respect to a single endpoint or target. However, computational chemogenomics (CG) has demonstrated benefits of learning from entire grids of data at once, rather than building target-specific QSARs. A possible reason for th...

Formal Agility. How much of each?

Agile Processes and Formal Methods (FM), water and oil, impossible mixture? Yes at first sight. Nevertheless, being formal methods weight processes and being agile processes informal approaches to software development, it is worth to study how much formal can be an agile process like Extreme Programming (XP) and how much agile can be a formal method. On our view, some XP practices are suitable ...